Edition 4, February 2015
NEWS
| Thin Film Approach to Biocatalysis (source: rsc.org) | Almac Group Announces £4.6m Research Partnership (source: portadowntimes.co.uk) |
Freeze-Dried Cells Make Better Biocatalysts (source: rsc.org) |
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UPCOMING EVENTS
| TRANSAM 2.0 - Chiral Amines Through (Bio)Catalysis | 3rd International Conference IMTB 2015 | ***** FEATURED EVENT: BIOTRANS 2015 ***** |
This conference aims to bring together researchers active in the area of enzymatic and chemical synthesis of chiral amines, and will provide a platform to exchange recent achievements from basic research to applied biocatalysis. Read more>>
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The IMTB conference aims to provide a platform for people from industry and academia, working in the cross-section of microfluidics, life sciences, analytics and bioprocess engineering. The interdisciplinary feature of the IMTB conferences enables participants to present and discuss their latest results, developments and strategies. Read more>>
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The 12th Biotrans, in cooperation with ACIB, covers all aspects of biocatalysis with special focus on enzyme mediated cascade reactions, enzyme discovery, bioinformatics, systems bio(techno)logy, protein engineering by directed evolution and/or rational design, enzyme immobilisation, process development and scale-up as well as manufacturing of chemical products using biocatalysis. Read more>> |
PRESENTING KYROBIO RESULTS
| Enantioselective Enzymes by Computational Design and In Silico Screening |
This paper was published in January 2015 and is supported by the Kyrobio project. Authors include Dr. Hein J. Wijma, Robert J. Floor, Dr. Sinisa Bjelic, Prof. Siewert J. Marrink, Prof. David Baker and Professor Dick B. Janssen from the University of Groningen in the Netherlands. Abstract: Computational enzyme design holds great promise for providing new biocatalysts for synthetic chemistry. A strategy to design small mutant libraries of complementary enantioselective epoxide hydrolase variants for the production of highly enantioenriched (S,S)-diols and (R,R)-diols is developed. Read more>> |
| Squalene Hopene Cyclases are Protonases for Stereoselective Brønsted Acid Catalysis |
| This paper has been published in the Journal Nature Chemical Biology and is supported by the Kyrobio project. Authors include Stephan C Hammer, Antonija Marjanovic, Jörg M Dominicus, Bettina M Nestl and Bernhard Hauern from the University of Stuttgart. Abstract: For many important reactions catalyzed in chemical laboratories, the corresponding enzymes are missing, representing a restriction in biocatalysis. Although nature provides highly developed machineries appropriate to catalyze such reactions, their potential is often ignored. Read more>> |
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Taking an unconventional approach to biocatalysis has allowed scientists in Italy to improve enzyme recyclability with a solvent-free reaction mixture. And by emphasising a need to design processes, biocatalysts and reactors together, instead of separately, they hope to widen the industrial applications of nature’s catalysts. 
Almac have announced another £4.6m research partnership with Queen’s University in the field of biocatalyst discovery and development.
The three-year project is backed with a £1.5m grant from Invest NI, part funded by the EU. 
A biocatalytic cascade using mashed-up cells has overcome extraction and solubility problems associated with using enzymes in chemical syntheses.
Enzymes are excellent catalysts for making chiral molecules. One-pot reactions under mild conditions are often possible with more than one catalyst, allowing multi-step syntheses in one go. 
Date: 04 to 06 March 2015 | Venue: Greifswald University, Germany
Date: 10 to 13 May 2015 | Venue: Opatija, Croatia
Date: 26 to 30 July 2015 | Venue: Vienna, Austria