C-Tech Innovation is a leading UK based, internationally focused, innovation management and technology development company. C-Tech’s in-house research group develops new products and technologies in collaboration with external partners both from academia and industry. Our activities in biotechnology focus on process design and scale up enabling higher quality products to be produced in vastly shortened time. Recent projects have focussed on the use of biocatalytic oxidase and transaminase based reactions to prepare functionalised chiral amines and amino acids.

As the project coordinator C-Tech will carry out the project management, using their extensive experience in managing EU & UK collaborative research projects and networks. C-Tech have nearly 20 years experience in collaborative projects and networks, acting as coordinator in many cases. Click here to view this partners website...




The evocatal GmbH is an industrial biotechnology company based in Duesseldorf, Germany, that was founded in 2006 as a spin-off of the Institute for Molecular Enzyme Technology at the University of Düsseldorf in the Forschungszentrum Jülich (Research Center Jülich). evocatal develops and produces enzymes and fine chemicals for the chemical and pharmaceutical industries.

We offer a catalog of enzymes (evozymes) as well as tailor-made biocatalysts for specific industrial applications. Our biocatalysts are applied in various consumer goods industries, including the production and refinement of textiles, adhesives, detergents, nutrition and cosmetics. evocatal’s technologies stand for effective and sustainable chemistry based on renewable resources. Click here to view this partners website...




BiCT is a start-up founded by partners coming from 20 years experience in bulk active pharmaceutical ingredients production through biocatalysis. BiCT expertise range from molecular biology until heterologous expression, purification and immobilization of biocatalysts for selective biotransformation. The main company goal is to provide cost-effective and industrial scale biocatalysts and bioprocesses, tailoring them on a client specific basis. Thanks also to a tight cooperation with Resindion srl, a subsidiary of Mitsubishi Chemicals Corporation producing chromatography and enzyme carrier resins, the BiCT technology on biocatalysis is currently applied in several processes in different fields (from food to pharma, from nutraceutics to cosmetics). The main R&D projects in biocatalysis are presently focused on immobilization on beads carriers, above all based on synthetic polymers. Click here to view this partners website...



Ingenza is a synthetic biology SME, based in the Roslin BioCentre that develops scalable industrial bioprocesses, applying engineered microbes for the manufacture of pharmaceuticals, biologicals, biofuels, food and agrochemicals. The company has a US partner and shareholder, Richmond Chemical Corporation, also an SME, involved in the manufacture and supply of fine chemicals to the pharmaceutical industry worldwide. Ingenza has developed critical enabling technologies in Industrial Biotechnology which it has integrated over the past 7 years to establish itself as a world leader in the adaptation of microbes for industrial use. The company currently has a staff of 24, employing 21 scientists, 10 of whom are qualified at Ph.D. level. The Ingenza scientific team spans the disciplines of molecular biology, biochemistry, enzymology, fermentation science and synthetic organic chemistry. The integration of these skills and technologies is unique in the UK and provides Ingenza with a strong competitive advantage with a diverse range of partners and end users, worldwide including fine chemical manufacturers, pharmaceutical companies and biopharma (therapeutic protein) companies. Click here to view this partners website...




"CLEA is a Life Sciences SME based in Delft, Netherlands that focuses on the development of green and cost-effective biocatalytic processes for the chemical and pharmaceutical industries. This encompasses the development of processes employing a broad range of enzymes, including various lyases, such as hydroxynitrile lyases, nitrile hydratases, halohydrin dehalogenases and aldolases, for use in enantioselective syntheses.The Company has proprietary technology for the immobilization of enzymes as Cross-Linked Enzyme Aggregates (CLEAs) including the co-immobilization of two or more enzymes in so-called combi-CLEAs. It is a key enabling technology for the development of industrial biotransformations as is reflected in the many benefits of CLEAs compared to free enzymes, e.g. simple procedure with broad scope, no need for pure enzyme, improved stability towards heat, organic solvents and autolysis, and high productivities.The company has key strategic links with the Department of Biotechnology of the Delft University of Technology." Click here to view this partners website...




“BioInfoBank Institute is a non-for-profit research and development organization. The general objective of the Institute is to generate, incubate and inspire innovative ideas and to facilitate and promote unrestricted and productive research conducted by highly motivated excellent young scientists in Poland. The Institute generates innovative technological solutions. Some of them are converted into commercial project ideas that can be disseminated across the BioInfoBank network. The institute not only educates experts in biotechnology and information technology but also promotes commercial exploitation of scientific discoveries by their own authors through a spin-off program. The main scientific focus of the institute is Bioinformatics, an inter-disciplinary field of science driven by achievements in biotechnology and information technology.” Click here to view this partners website...



Prozomix Limited is a privately owned research orientated biotechnology SME founded in 2008. The company, located in Haltwhistle, in the North of England, develops, produces and supplies a large, diverse and rapidly expanding range of novel enzymes and related advanced products and services, with a focus on Biocatalysis. In 2011, Prozomix launched a cost-effective “Biocatalysis Enzyme Toolkit”, comprising expanding panels of recombinant biocatalysts, populated using a rational bioinformatics approach, in conjunction with proprietary high-throughput cloning methodology, collectively referred to as GRASPTM (Genomics-based Related Activity Screening Protocol). Prozomix is currently using its GRASPTM technology to increase the number of unique enzymes comprising its Biocatalysis Enzyme Toolkit to more than 1000 over the next two years. Toolkit enzymes are obtained free-of-charge, with a “hit fee” only being paid when an enzyme of interest is identified by the customer against their specific application. Click here to view this partners website...




VTU Technology is a leading contract research and development company, providing services for the fast track generation for high performance, industrial protein production strains and economically viable protein production processes for pharmaceutical companies and any other protein manufacturer.

VTU´s exclusive Pichia pastoris expression platform is based on its 1st and 2nd generation AOX1 promoter libraries, best suited for economic protein production. Applied by VTU´s sophisticated team, this cutting-edge platform facilitates the delivery of unparalleled expression levels often achieving more than 10 g/L secreted protein (20 g/L peak expression level) within a few weeks development time including serum proteins, cytokines, Fabs, antibody derived fragments, scaffold proteins, fusion proteins and enzymes. Click here to view this partners website...




X-Zyme is the enzyme development center of Johnson Matthey Catalysis and Chiral Technology (CCT). Started as a small Biotech Company based in Düsseldorf, dedicated to the discovery and development of novel biocatalysts for application in fine chemicals and pharmaceutical industry, X-Zyme was acquired by Johnson Matthey in 2010. The addition of X-Zyme technology to the existing platform of heterogeneuos, cross-coupling, and chiral homogeneous catalysts strenghtened Johnson Matthey leadership in the catalysis market.
The fast growing X-Zyme portfolio includes a robust platform of ketoreductases for the asymmetric reduction of ketones to the corresponding chiral secondary alcohols, a big range of esterases and other hydrolitic enzymes, as well as the increasingly interesting classes of transaminases and ene reductases. Click here to view this partners website...




Bio-Prodict, a spin-off company of the Wageningen University, is specialized in bio-informatics related services. The main focus of Bio-Prodict is data mining, storage and analysis of protein (super-family) data.

Bio-Prodict has developed 3DM, a tool that can automatically generate super-family specific databases designed to guide scientific research in the field of protein engineering, drug design and DNA-diagnostics. 3DM databases are custom made protein super-family systems. These systems have proven to be powerful tools for the understanding of different protein features and the prediction of effects of mutations. 3DM is connected to the state of the art protein visualization tool YASARA (see www.yasara.org) which enables automated visalization of 3DM data in protein structure files. Click here to view this partners website...




The ACIB competence centre is a multidisciplinary centre of more than 120 scientists devoted to the development of better bioprocesses. ACIB combines the experience and synergy of the AB (Research Centre Applied Biocatalysis) and ACBT (Austrian Centre of Biopharmaceutical Technology).

It has a strong track record in enzyme discovery and industrial production strain development. One focus of ACIB is close partnership with the university partners to discover and redesign of enzymes for industrial use and to enable their economic production. Successful examples include pig liver esterases and plant enzymes (e.g. hydroxyl nitrile lyases) which were engineered for industrial applications on multi ton scale.

ACIB participates in KYROBIO together with his third party TU Graz- Click here to view this partners website...




Wolfgang Kroutil’s group is located at the Institute of Chemistry of the University of Graz. The University of Graz (founded in 1585) is one of the largest institutions of higher education in Austria. With more than 30,000 students (ca. 12% foreigners) and 3,800 employees (2,600 scientific staff), it makes an essential contribution to the vibrant life of the Styrian capital. The group has extensive experience in (a) applying enzymes for organic synthesis, (b) designing non-natural substrates for enzymes, (c) investigating enzyme mechanisms using (labelled) model compounds and radical clocks, (d) expanding the possible range of reactions of enzymes (enzyme „promiscuity“), (d) enzyme identification, characterisation and purification and (e) in enzyme cascades. Click here to view this partners website...




Centre of Excellence in biocatalysis, Biotransformations & Biocatalytic Manufacture (CoEBio3)

The Manchester Interdisciplinary Biocentre is home to the Centre of Excellence in Biocatalysis, Biotransformations and Biocatalytic Manufacture (CoEBio3), a research centre dedicated to developing novel biocatalytic processes for industry. CoEBio3 has key strategic links with the Universities of York, Strathclyde and Heriot-Watt Universities as well as the National Industrial Biotechnology Facility (NIBF) which is based within the Centre for Process Innovation at Wilton, Redcar, UK. CoEBio3 supply the research, training and development services to enable the application of white biotechnology to produce chemical entities with an applied “genes to kilos” philosophy.

The research group of Prof. Nick Turner has ca. 25 years experience in biocatalysis and has published ca. 300 papers in this field. The Turner group has worked with a wide range of different enzymes including alcohol oxidases (galactose oxidase), amine oxidases, aldolases, ammonia lyases, P450s, and enoate reductases. Their interdisciplinary CoEBio3 laboratories are fully equipped to be able to carry out organic synthesis, analytical chemistry, microbiology, protein biochemistry, molecular biology and protein modelling. Click here to view this partners website...




The Biotransformation and Biocatalysis group led by Prof. Dick Janssen has outstanding expertise in the field of biotransformations of synthetic compounds. This includes enzyme discovery by genome mining and by using metagenome strategies, expression, purification and mechanistic analysis of new enzymes, and exploration of their biocatalytic scope and application in green chemistry. The Protein Crystallography group is led by Prof. Bauke Dijkstra and has solved many structures and mechanisms of enzymes of biocatalytic relevance, including lipases, dehalogenases, epoxide hydrolases, and lyases. The results of the structural investigations guide joined protein engineering and directed evolution projects that are aimed at improving enzymes for industrial application. Click here to view this partners website...




The Institute of Technical Biochemistry at the Universitaet Stuttgart is led by Prof. Dr. Bernhard Hauer and covers biocatalysis, functional biomaterials, molecular biotechnology, fermentation and bioinformatics. The interdisciplinary research focuses on the cloning, expression, characterization and optimization of enzymes including P450 monooxygenases, lipases, enoate reductases, dehydratases and cyclases. Methods of laboratory evolution are used to generate novel and improved biocatalysts for industrial applications. The laboratories are equipped to implement analytical chemistry, microbiology, protein biochemistry and molecular biology. The research requires contributions from many disciplines, including chemistry, biochemistry, molecular biology, microbiology, bioengineering and bioinformatics. Click here to view this partners website...




The Process Engineering and Technology Group at DTU are within the Department of Chemical and Biochemical Engineering, and headed by Prof. John Woodley. The group has extensive experience in process technology (in particular for enzyme-based reactions), scale-up and scale-down, process modelling and simulation as well as reactor and process design and pilot scale validation for a range of enzyme-based synthetic systems.

The group develops and uses process engineering tools to facilitate the rapid and effective implementation of new and innovative processes for industry. To this end economical and environmental assessment tools as well as software and methodologies for e.g. property prediction and the use of operating windows are employed. Click here to view this partners website...




KTN is funded by the UK government to speed up innovation, solve problems and find markets for new ideas. KTN was established to foster better collaboration between science, creativity and business. The main aim is to help the chemistry using industries in the UK to access, from a single source, the knowledge base in science, engineering and manufacturing, thereby enabling those industries to innovate faster and more successfully. It is not limited to the traditional chemical industry and covers any sector which uses chemistry and spans materials, biotechnology, home and personal care, food and other industries which rely on chemistry in some aspect of their business. A current major challenge enabling businesses to understand the implications of renewable feedstocks and industrial biotechnology, stimulating companies to innovate in bio based products.

KTN has a core team with deep, diverse experience in business, innovation, knowledge transfer, chemistry and chemical engineering – most with many years of experience as front-line practitioners and managers at senior levels. Dissemination is one of its key skills. KTN also acts as the UK National Platform for SusChem (the European Technology Platform for Sustainable Chemistry). Consequently it is linked to the central SusChem activities, managed from within Cefic (the European Chemical Industry Council) and also to EuropaBio and all the National SusChem Platforms in other Member States. Click here to view this partners website...